Slow membrane currents in bursting pace-maker neurones of Tritonia.

Role of membrane potential in calcium signaling during rhythmic bursting in tritonia swim interneurons.

Rhythmic bursting in neurons is accompanied by dynamic changes in intracellular Ca(2+) concentration. These Ca(2+) signals may be caused by membrane potential changes during bursting and/or by synaptic inputs. We determined that membrane potential is responsible for most, if not all, of the cytoplasmic Ca(2+) signal recorded during rhythmic bursting in two neurons of the escape swim central pat...

Slow outward tail currents in molluscan bursting pacemaker neurons: two components differing in temperature sensitivity.

Bursting pacemaker neurons of Tritonia and Aplysia were studied in voltage-clamp experiments to determine the ionic requirements of the slow outward tail current. This current is important for terminating bursts and hyperpolarizing the neuron during the interval between bursts and therefore contributes to the timing of pacemaker activity. A method for rapid extracellular perfusion of the neuron...

An unusual complication of a ventricular pace maker electrode.

The pace Maker of the Cardiac Ganglion of Limulus .polyphemus

The ganglion on the dorsal surface of the heart of Limulus polyphemus originates the impulses which cause the contractions of the cardiac muscle (1). In large specimens the portion of the dorsal nerve cord which contains the ganglion cells may be 10 or even 12 cm. in length and one naturally wonders where in the extent of this long structure the impulse actually arises. Does it arise in a speci...

Increased bursting in layer 2/3 neurones of awake neocortex.

A central goal of neuroscience is to relate the biophysical properties of neurones to network function and ultimately to behaviour. This requires knowledge of cellular mechanisms in intact circuits, where neurones retain their full complement of synaptic connections and can be stimulated with their natural sensory inputs. Major efforts have been made toward this goal in the last decade as in vi...